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Dr. Paul focuses in this episode on the factors that lead to mental and other physical health issues. The main factors are genetic predisposition/family history, which is the number one cause. The second cause is that hormonal imbalances lead to neurochemical imbalances, and there are several times of life when this occur such as puberty, premenstrual, postpartum, pre-, peri-and postmenopausal. These hormonal imbalances occur in men and women. A third factor is severe stressors that can occur in life. Other factors include weather and seasonal patterns as well as others.